A spatial frequency-doubling illusion-based pattern electroretinogram for glaucoma.

T Maddess; A C James; I Goldberg; S Wine; J Dobinson

Home/Archive/PubMed

PubMed · 11053281

A spatial frequency-doubling illusion-based pattern electroretinogram for glaucoma.

T Maddess·A C James·I Goldberg·S Wine·J Dobinson

View original source ↗Export metadata ↓

Abstract

PURPOSE: A pattern electroretinogram (PERG) in which stimuli displaying the frequency-doubling (FD) illusion are presented simultaneously to multiple parts of the visual field was evaluated for its ability to diagnose glaucoma. This multiregion FD PERG is referred to in the current study as the MFP. METHODS: The nine stimulus regions were temporally modulated at incommensurate frequencies typically producing an FD percept. Two other spatial scales of the stimuli were also investigated. The sensitivity and specificity of MFP were examined using linear and quadratic discriminant methods. RESULTS: Even with the simpler linear discriminant classification, sensitivities and specificities of 100% were obtained in eyes with moderate to severe glaucoma. Of eyes with glaucoma strongly suspected, 67% were classified as being glaucomatous. Stimulus patterns having differing spatial scales produced different PERG visual field dependencies. CONCLUSIONS: The differing results for the 16-fold change in spatial scale may reflect the accessing of different mechanisms. The MFP method appears to have significant value for the diagnosis of glaucoma.

Explore related subjects

Electroretinography Glaucoma, Angle-Closure Glaucoma, Open-Angle Humans Illusions Middle Aged Ocular Hypertension Sensitivity and Specificity Visual Fields Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

T Maddess, A C James, I Goldberg, S Wine, J Dobinson. 2000. A spatial frequency-doubling illusion-based pattern electroretinogram for glaucoma.. https://pubmed.ncbi.nlm.nih.gov/11053281/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2002

Reproducibility of multifocal ERG using the scanning laser ophthalmoscope.

BACKGROUND: Prior to application of multifocal electroretinography (mfERG) using the scanning laser ophthalmoscope (SLO) in a clinical routine setting it is important to determine the reproducibility of this technique in normals during the use of monochromatic red HeNe laser light. METHODS: Thirty-five eyes of 35 volunteers (visual acuity > or =0.8) were examined using the SLO for mfERG with two test patterns in a 20-deg diameter field. Multifocal ERG was performed using the RETIscan system with a binary m-sequence technique. Evaluation was performed for the first-order kernel concentric ring segments. Three measurements were performed for each type of sequence (six sequences for seven hexagons, eight for 19 hexagons) with removal of electrodes between the recordings. Stimulus intensity for all subjects was set to 235 cd/m2 (background illumination 20 cd/m2). We used gold-foil electrodes to obtain good signal quality while not disturbing corneal transmission and refraction. RESULTS: The coefficient of variation for the P1 amplitudes for the center and surrounding ring(s) was 10.4% and 9.3% for seven hexagons and 15.2%, 9.3% and 7.6%, for 19 hexagons, respectively. The corresponding intraclass correlation coefficients varied between 0.59 and 0.77. The CV for the P1 peak times varied between 1.3% and 1.5% for ring analysis in seven and 19 hexagons. CONCLUSION: Our data shows that the setup of mfERG with the SLO provides a retest variability comparable with conventional CRT examinations. One advantage is the simultaneous visualization of the fundus with observation of fixation during examination, thereby allowing more confidence in pathological results.

Electroretinography↗

PubMed2002

Multifocal electroretinography response after laser photocoagulation of a subretinal nematode.

PURPOSE: To describe multifocal electroretinography findings before and after laser photocoagulation of a subretinal nematode in diffuse unilateral subacute neuroretinitis. METHOD: Observational case report. A 45-year-old woman with left eye inflammation, subretinal tracts superior and temporal to the fovea, and a subretinal coiled mobile parasite was treated with laser photocoagulation to destroy the nematode. Multifocal electroretinography was performed before and after laser photocoagulation. RESULTS: In the left eye, multifocal electroretinography before treatment showed decreased foveal response density and increased parafoveal and perifoveal waveform amplitudes. Two months after laser photocoagulation, multifocal electroretinography showed full recovery of normal findings and the visual acuity remained 20/20. CONCLUSION: Multifocal electroretinography appears to be useful in evaluating the retinal findings after photocoagulation of a parasite associated with diffuse unilateral subacute neuroretinitis.

Electroretinography↗

PubMed2002

Detection of optic neuropathy in glaucomatous eyes with normal standard visual fields using a test battery of short-wavelength automated perimetry and pattern electroretinography.

PURPOSE: To evaluate the clinical use of a test battery of short-wavelength automated perimetry (SWAP), frequency-doubling technology (FDT) perimetry, and pattern-electroretinography (PERG) in patients with definite primary open-angle glaucoma (POAG) but normal results on standard automated perimetry (SAP). STUDY DESIGN: Prospective, comparative, observational case series. PARTICIPANTS: Thirty-six patients with POAG with standard visual field defects in one eye and normal standard visual fields in the contralateral eye and 36 normal controls were enrolled. MAIN OUTCOME MEASURES: SWAP, PERG, FDT, and SAP were performed in all eyes, and global indices and amplitudes were used for statistical analysis. RESULTS: When contralateral POAG eyes with asymmetric glaucomatous damage was compared, a paired t test showed significant differences in SAP mean deviation (MD) (P < 0.0001), SWAP-MD (P = 0.0003), FDT-MD (P = 0.0008), and PERG amplitudes (P < 0.0001). When comparing between POAG eyes with normal results on SAP and normal controls, Student's t test showed significant differences for SWAP-MD (P < 0.0001), FDT-MD (P = 0.0006), PERG N1P1-amplitude (P = 0.0486) and P1N2-amplitude (P < 0.0001); receiver operating characteristic analysis revealed promising accuracy for SWAP-MD of 73.6% (P < 0.0001). SWAP-MD (P < 0.0001) and FDT-MD (P < 0.0001) correlated significantly with SAP-MD and with each other (range, P < 0.0001 to P = 0.0020). Regression analysis revealed that PERG P1N2-amplitude could improve the power of SWAP-MD from 73.6% to detect early POAG in eyes with normal results on SAP to an accuracy of 81.9%. CONCLUSIONS: A test battery of SWAP-MD and PERG P1N2-amplitude could detect glaucomatous optic neuropathy in POAG eyes with normal standard visual fields, whereas FDT-MD and SWAP-MD significantly correlated with each other and with SAP-MD. All tests were able to detect the eye with the more severe glaucomatous optic neuropathy in patients with asymmetric POAG.

Electroretinography↗