Intestinal amoebiasis: delayed-type hypersensitivity response in mice.

P K Ghosh; S Gupta; L Ortiz-Ortiz

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PubMed · 11057067

Intestinal amoebiasis: delayed-type hypersensitivity response in mice.

P K Ghosh·S Gupta·L Ortiz-Ortiz

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Abstract

Delayed-type hypersensitive (DTH) response was evaluated in C3H/HeJ mice intestinally infected with Entamoeba histolytica. Infected and non-infected control mice were challenged with amoebic antigen on day 5, 10, 15, 20, 25, 30, 40, 50, and 60 post-infection. Maximum footpad swelling was observed after 24 hours of the challenge. The E. histolytica-infected mice exhibited a DTH response on day 5, 15, 20, 25, 40 and 60 post-infection. However, on day 10, 30, and 50, such response was similar to that of the non-infected control mice. The mice developed an evident DTH response late in the course of infection (25 days post-infection). The infected mice did not show any alteration to their DTH response against heterologous unrelated antigen (sheep red blood cells), suggesting that cellular anergy was antigen-specific.

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Animals Disease Models, Animal Dysentery, Amebic Entamoeba histolytica Hypersensitivity, Delayed Immunity, Cellular Mice Mice, Inbred C3H Time Factors Journal Article

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P K Ghosh, S Gupta, L Ortiz-Ortiz. 2000. Intestinal amoebiasis: delayed-type hypersensitivity response in mice.. https://pubmed.ncbi.nlm.nih.gov/11057067/

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