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Salt-induced DNA-histone complexation.

K K Kunze·R R Netz
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Abstract

We study numerically the binding of one semiflexible charged polymer onto an oppositely charged sphere. Using parameters appropriate for DNA-histone complexes, we find complete wrapping for intermediate salt concentrations only, in agreement with experiments. For high salt concentrations, a strongly discontinuous dewrapping occurs. For low salt concentrations, we find multiple conformational transitions, leading to an extended DNA configuration. The wrapped states are characterized by spontaneously broken rotational and mirror symmetries, giving rise to four distinct structures.

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K K Kunze, R R Netz. 2000-11-13. Salt-induced DNA-histone complexation.. https://doi.org/10.1103/physrevlett.85.4389

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