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PubMed · 11061346

Endothelial dysfunction in the pulmonary vascular bed.

Y F Chen·S Oparil
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Abstract

The pulmonary endothelium modulates vascular tone by the release of endothelium-derived constricting (EDCF) and relaxing (EDRF) factors, among them endothelin-1, nitric oxide, prostacyclin, and putative endothelium-derived hyperpolarizing factors. Abnormalities in EDCF and EDRF generation have been demonstrated in a number of cardiopulmonary disease states, such as primary and secondary pulmonary hypertension, chronic obstructive lung disease, cardiopulmonary bypass, and congestive heart failure. An imbalance between EDCF and EDRF, termed "pulmonary endothelial dysfunction," may contribute to the alteration in vascular tone characteristic of pulmonary disease. The following review summarizes the present knowledge of the role of EDCF and EDRF in such processes with major focus on pulmonary endothelial dysfunction in hypoxia-induced pulmonary hypertension.

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AnimalsAntihypertensive AgentsAtrasentanBosentanControlled Clinical Trials as TopicDisease Models, AnimalEndothelin Receptor AntagonistsEndothelin-1EndothelinsEndothelium, VascularEpoprostenolHeart FailureHumansHypertension, PulmonaryHypoxiaLung Diseases, ObstructiveNitric OxideOligopeptidesPeptides, CyclicPiperidinesPulmonary CirculationPyrrolidinesRNA, MessengerReceptors, EndothelinSulfonamidesTime FactorsVasoconstrictionVasodilationJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Y F Chen, S Oparil. 2000. Endothelial dysfunction in the pulmonary vascular bed.. https://doi.org/10.1097/00000441-200010000-00001

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