Decoding calcium signals involved in cardiac growth and function.

N Frey; T A McKinsey; E N Olson

doi:10.1038/81321

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PubMed · 11062532

Decoding calcium signals involved in cardiac growth and function.

N Frey·T A McKinsey·E N Olson

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Abstract

Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological modification of cardiac function.

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Animals Calcium Signaling Calmodulin Cardiomegaly Gene Expression Regulation Heart Humans Myocardial Contraction Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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N Frey, T A McKinsey, E N Olson. 2000. Decoding calcium signals involved in cardiac growth and function.. https://doi.org/10.1038/81321

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