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S100-annexin complexes: some insights from structural studies.

A Lewit-Bentley·S Réty·J Sopkova-de Oliveira Santos·V Gerke
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Abstract

Several annexins have been shown to bind proteins that belong to the S100 calcium-binding protein family. The two best-characterized complexes are annexin II with p11 and annexin I with S100C, the former of which has been implicated in membrane fusion processes. We have solved the crystal structures of the complexes of p11 with annexin II N-terminus and of S100C with annexin I N-terminus. Using these structural results, as well as electron microscopy observations of liposome junctions formed in the presence of such complexes (Lambert et al., 1997 J Mol Biol 272, 42-55), we propose a computer generated model for the entire annexin II/p11 complex.

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Annexin A2Crystallography, X-RayDimerizationModels, MolecularMolecular StructurePeptidesProtein BindingProtein ConformationS100 ProteinsS100 Calcium Binding Protein A10Journal ArticleResearch Support, Non-U.S. Gov't

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A Lewit-Bentley, S Réty, J Sopkova-de Oliveira Santos, V Gerke. 2000. S100-annexin complexes: some insights from structural studies.. https://doi.org/10.1006/cbir.2000.0629

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