Triazine-based condensing reagents.

Z J Kamiński

doi:10.1002/1097-0282(2000)55:2<140::aid-bip40>3.0.co;2-b

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PubMed · 11074411

Triazine-based condensing reagents.

Z J Kamiński

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Abstract

The synthesis, properties, and application of condensing reagents derived from 1,3,5-triazines are described. The mechanism of activation of carboxylic function, structure of reactive intermediates, and mechanism of acylation of nucleophiles are presented. The synthetic versatility of mono- and bifunctional reagents for syntheses in solution, triazine-based immobilized reagents, chiral triazines for enantiodifferentiating syntheses, are discussed. The scope and limitation of the synthetic utility of triazine reagents in the preparation of heterocyclic compounds, amides, esters, oligopeptides-including large-scale syntheses and use in the combinatorial chemistry-is demonstrated.

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Combinatorial Chemistry Techniques Peptides Polymers Polysaccharides Stereoisomerism Triazines Journal Article Research Support, Non-U.S. Gov't Review

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Z J Kamiński. 2000. Triazine-based condensing reagents.. https://doi.org/10.1002/1097-0282(2000)55%3A2%3C140%3A%3Aaid-bip40%3E3.0.co%3B2-b

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