Eukaryotic DNA primase.

B Arezi; R D Kuchta

doi:10.1016/s0968-0004(00)01680-7

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Eukaryotic DNA primase.

B Arezi·R D Kuchta

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Abstract

Eukaryotic DNA primase initiates the synthesis of all new DNA strands by synthesizing short RNA oligomers on single-stranded DNA. Additionally, primase helps couple replication and repair and is critical for telomere maintenance and, therefore, chromosome stability. In light of the many aspects of DNA metabolism in which primase is involved, understanding the unique features of the mechanism of this enzyme and how it interacts with other proteins will greatly advance our knowledge of DNA replication and repair.

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Amino Acid Sequence Animals DNA Polymerase I DNA Primase DNA Repair Eukaryotic Cells Humans Molecular Sequence Data Journal Article Research Support, U.S. Gov't, P.H.S.Review

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B Arezi, R D Kuchta. 2000. Eukaryotic DNA primase.. https://doi.org/10.1016/s0968-0004(00)01680-7

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