Dopamine uptake blockers nullify methamphetamine-induced decrease in dopamine uptake and plasma membrane potential in rat striatal synaptosomes.

R I Westphalen; A Stadlin

doi:10.1111/j.1749-6632.2000.tb05195.x

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Dopamine uptake blockers nullify methamphetamine-induced decrease in dopamine uptake and plasma membrane potential in rat striatal synaptosomes.

R I Westphalen·A Stadlin

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Abstract

Rat striatal synaptosomes showed a reduced capacity to generate a membrane potential after being exposed to methamphetamine (METH) for 1 h. As a consequence, the dopamine (DA) synaptosomes were impeded in their electrogenic-dependent reuptake of dopamine. The capacity for METH-exposed nerve terminals to generate a membrane potential may contribute to the ability of METH to destroy dopaminergic neurons. DA uptake inhibitors (DAUIs) were found to counteract the METH-induced decrease in synaptosomal [3H]DA Vmax by stablizing METH-induced reductions in PMP. Because DAUIs showed the same effects as a Na+-channel blocker, DAUIs may prevent METH-induced destruction of dopaminergic neurons by raising plasma membrane potential.

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Animals Antioxidants Corpus Striatum Dopamine Dopamine Uptake Inhibitors Drug Combinations Membrane Potentials Methamphetamine Plasma Radioligand Assay Rats Rats, Sprague-Dawley Synaptosomes Tritium Vinca Alkaloids Comparative Study Journal Article

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R I Westphalen, A Stadlin. 2000. Dopamine uptake blockers nullify methamphetamine-induced decrease in dopamine uptake and plasma membrane potential in rat striatal synaptosomes.. https://doi.org/10.1111/j.1749-6632.2000.tb05195.x

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