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PubMed · 11085459

Anti-CD30 antibody-based therapy.

H B Koon·R P Junghans
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Abstract

The increased expression of CD30 on some neoplasms versus its limited expression on normal tissue makes it an excellent target for antibody-based therapy. Recent studies have shown that anti-CD30 antibodies may serve as signaling molecules as well as mediators of interactions with the immune system. Unmodified anti-CD30 antibodies as well as anti-CD30-based bispecific antibodies, immunotoxins, and radioimmunoconjugates have been examined in preclinical and clinical studies. The data show that anti-CD30-based therapies are promising new treatment modalities for CD30+ neoplasms.

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AntibodiesAntibodies, BispecificClinical Trials as TopicHumansImmunotoxinsKi-1 AntigenModels, BiologicalNeoplasmsRadioimmunotherapyReceptors, IgGJournal ArticleReview

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BibTeXRIS

H B Koon, R P Junghans. 2000. Anti-CD30 antibody-based therapy.. https://doi.org/10.1097/00001622-200011000-00012

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