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The ACE I/D polymorphism and human physical performance.

D R Woods·S E Humphries·H E Montgomery
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Abstract

The D allele of the angiotensin-converting enzyme (ACE) I/D polymorphism is associated with elevated levels of serum and tissue ACE, increased production of the vasopressor angiotensin II and a reduction in the half-life of the vasodilator bradykinin. Several cardiac and renal conditions appear to have a worse prognosis in subjects homozygous for the D allele, whereas the I allele has been associated with enhanced endurance performance in elite distance runners, rowers and mountaineers. The nature of the gene-environment interaction between ACE I/D polymorphisms and physical training, an overview of recent findings and a discussion of possible underlying mechanisms is the subject of this review.

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HumansIsoenzymesPeptidyl-Dipeptidase APhysical FitnessPolymorphism, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tReview

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D R Woods, S E Humphries, H E Montgomery. 2000. The ACE I/D polymorphism and human physical performance.. https://doi.org/10.1016/s1043-2760(00)00310-6

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