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Spin Frustration in a Dimeric Mn(II) Complex with a Metallocene-Substituted alpha-Nitronyl Nitroxide Radical This work was supported by grants from DGES (project PB96-0802-C02-01), CIRIT (project SGR 96-00106), Fonds zur Förderung der Wissenschaftlichen Forschung, Vienna (Project P 13128), Austrian Federal Ministry of Science (BMWV), Acción Integrada Hispano-Austríaca (HU-1999-0015), and the 3MD Network of the TMR program of the E.U. (contract ERBFMRX CT980181). C.S. thanks the Austrian Federal Ministry of Science for the award of a research scholarship. D.R.-M. thanks the Generalitat de Catalunya for a postdoctoral grant. The authors acknowledge the suggestions given by one of the referees.

D Ruiz-Molina·C Sporer·K Wurst·P Jaitner·J Veciana
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D Ruiz-Molina, C Sporer, K Wurst, P Jaitner, J Veciana. 2000-10-16. Spin Frustration in a Dimeric Mn(II) Complex with a Metallocene-Substituted alpha-Nitronyl Nitroxide Radical This work was supported by grants from DGES (project PB96-0802-C02-01), CIRIT (project SGR 96-00106), Fonds zur Förderung der Wissenschaftlichen Forschung, Vienna (Project P 13128), Austrian Federal Ministry of Science (BMWV), Acción Integrada Hispano-Austríaca (HU-1999-0015), and the 3MD Network of the TMR program of the E.U. (contract ERBFMRX CT980181). C.S. thanks the Austrian Federal Ministry of Science for the award of a research scholarship. D.R.-M. thanks the Generalitat de Catalunya for a postdoctoral grant. The authors acknowledge the suggestions given by one of the referees.. https://doi.org/10.1002/1521-3773(20001016)39%3A20%3C3688%3A%3Aaid-anie3688%3E3.0.co%3B2-6

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Effectiveness of high-dose versus standard-dose influenza vaccines against hospitalisation according to frailty risk: a prespecified analysis of the randomised trial DANFLU-2.

BACKGROUND: Frailty is a major risk factor for influenza-related complications and can influence vaccine effectiveness. We aimed to assess the relative vaccine effectiveness (rVE) of high-dose (HD-IIV) versus standard-dose inactivated influenza vaccine (SD-IIV) in older adults aged 65 years or older according to frailty risk. METHODS: This study was a prespecified analysis of DANFLU-2, an open-label, individually randomised trial, conducted in Denmark during three consecutive influenza seasons (2022-23, 2023-24, and 2024-25). Adults aged 65 years or older were randomised (1:1) to the HD-IIV or SD-IIV group. The primary endpoint was hospitalisation for influenza or pneumonia. Frailty was defined according to the validated Hospital Frailty Risk Score (HFRS) based on ICD-10 codes within 10 years before randomisation. Participants were stratified into three HFRS categories, namely low (<5 points), intermediate (5-15 points), and high (>15 points) frailty risk. The rVE of HD-IIV versus SD-IIV against the primary endpoint was assessed across prespecified HFRS categories and treating HFRS as a continuous variable. Pearson's chi-square test was used to compare safety events across frailty risk groups and randomisation groups. FINDINGS: Among 332&#x2009;438 randomised participants (mean age 73&#xb7;7 years [SD 5&#xb7;8]; 161&#x2009;538 [48&#xb7;6%] were female), 276&#x2009;173 (83&#xb7;1%) had low frailty risk, 52&#x2009;395 (15&#xb7;8%) had intermediate frailty risk, and 3861 (1&#xb7;2%) had high frailty risk. The primary endpoint of hospitalisation for influenza or pneumonia occurred in 1424 (0&#xb7;5%) of 276&#x2009;173 participants with low frailty risk, 761 (1&#xb7;5%) of 52&#x2009;395 with intermediate frailty risk, and 163 (4&#xb7;2%) of 3861 with high frailty risk (relative risk [RR] for intermediate vs low frailty risk 2&#xb7;8 [95% CI 2&#xb7;6-3&#xb7;1]; RR for high vs low frailty risk 8&#xb7;2 [7&#xb7;0-9&#xb7;6]). HFRS as a continuous variable significantly modified the effect of HD-IIV versus SD-IIV against the primary endpoint with higher rVE estimates with increasing HFRS (pinteraction=0&#xb7;020). The rVE was 0&#xb7;2% (95% CI -10&#xb7;8 to 10&#xb7;2) among those with low frailty risk, 13&#xb7;1% (-0&#xb7;4 to 24&#xb7;8) among those with intermediate frailty risk, and 19&#xb7;9% (-10&#xb7;3 to 42&#xb7;1) among those with high frailty risk. No significant interaction was observed when HFRS was assessed according to the prespecified categorical frailty groups (pinteraction=0&#xb7;17). The proportion of participants with at least one serious adverse event increased across frailty risk groups (13&#x2009;366 [4&#xb7;8%] of 275&#x2009;795 for low frailty risk, 5475 [10&#xb7;5%] of 52&#x2009;315 for intermediate frailty risk, and 777 [20&#xb7;2%] of 3850 for high frailty risk; p<0&#xb7;0001), with similar proportions of serious adverse events in the HD-IIV and SD-IIV groups for each frailty risk group. INTERPRETATION: Among adults aged 65 years or older in Denmark, frailty risk might modify the effects of HD-IIV versus SD-IIV against hospitalisation for influenza or pneumonia, with higher rVE estimates with increasing frailty risk. These findings might support considering high-dose influenza vaccines for frail older adults. However, effect modification was not evident when frailty was assessed using prespecified categorical subgroups, and subgroup-specific estimates were imprecise, with 95% CIs crossing the null. These results should be considered exploratory, warranting further investigation. FUNDING: The DANFLU-2 trial was funded by Sanofi.

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