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PubMed · 11100129

Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'.

B Prakken·M Wauben·D Genini·R Samodal·J Barnett·A Mendivil·L Leoni·S Albani
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Abstract

Recent progress in molecular medicine has provided important tools to identify antigen-specific T cells. In most cases, the approach is based on oligomeric combinations of recombinant major histocompatibility complex-peptide complexes fixed to various rigid supports available for binding by the T-cell receptor. These tools have greatly increased our insight into mechanisms of immune responses mediated by CD8+ T cells. Examples of the diverse fields of application for this technology include immunization, viral infections and oral tolerance induction.

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Antigen PresentationCD8-Positive T-LymphocytesHistocompatibility Antigens Class IIImmune ToleranceImmunologic TechniquesLiposomesPeptidesVaccinationJournal Article

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B Prakken, M Wauben, D Genini, R Samodal, J Barnett, A Mendivil, L Leoni, S Albani. 2000. Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'.. https://doi.org/10.1038/82231

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