The DNA damage response: putting checkpoints in perspective.

B B Zhou; S J Elledge

doi:10.1038/35044005

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The DNA damage response: putting checkpoints in perspective.

B B Zhou·S J Elledge

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Abstract

The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.

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Animals Ataxia Telangiectasia Mutated Proteins Cell Cycle Cell Cycle Proteins Checkpoint Kinase 1 Checkpoint Kinase 2 DNA Damage DNA Repair DNA-Binding Proteins Forecasting Humans Protein Kinases Protein Serine-Threonine Kinases Signal Transduction Tumor Suppressor Proteins Journal Article Review

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B B Zhou, S J Elledge. 2000-11-23. The DNA damage response: putting checkpoints in perspective.. https://doi.org/10.1038/35044005

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