T cell differentiation: a mechanistic view.

O Avni; A Rao

doi:10.1016/s0952-7915(00)00158-8

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T cell differentiation: a mechanistic view.

O Avni·A Rao

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Abstract

It has recently become clear that cytokine expression by T cells involves epigenetic changes in chromatin structure, locus accessibility and DNA methylation that occur during differentiation of naive T cells into mature effector T cells. These changes require the coordinate actions of antigen- and cytokine-induced transcription factors, chromatin remodeling complexes, histone-modifying enzymes and subset-specific transcription factors.

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Animals Chromatin Humans Leukopoiesis Lymphocyte Activation T-Lymphocytes Transcription Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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O Avni, A Rao. 2000. T cell differentiation: a mechanistic view.. https://doi.org/10.1016/s0952-7915(00)00158-8

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