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PubMed · 11105900

Function of CBFbeta/Bro proteins.

N Adya·L H Castilla·P P Liu
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Abstract

Mammalian core binding factor beta (CBFbeta) and Drosophila Brother (Bro) and Big-brother (Bgb) proteins are transcription factors that dimerize with mammalian Runx and Drosophila Runt and Lozenge proteins and augment their DNA binding affinity and transcriptional potency. CBFbeta is essential for development and sustenance of definitive hematopoiesis during mouse embryogenesis. Bro and Bgb are required for Runt/Lozenge functions in Drosophila development. CBFbeta contributes to leukemogenesis since the CBFB gene is specifically and consistently mutated by a chromosome 16 inversion found in patients with acute myeloid leukemia subtype M4Eo. The ubiquitous expression pattern of the CBFB gene suggests that it may play important roles in many other organ systems.

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Amino Acid SequenceAnimalsCore Binding Factor Alpha 2 SubunitCore Binding Factor beta SubunitDNA-Binding ProteinsDrosophila ProteinsEmbryonic and Fetal DevelopmentHumansInsect ProteinsLeukemiaMolecular Sequence DataProto-Oncogene ProteinsSequence AlignmentTranscription Factor AP-2Transcription FactorsTranslocation, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tReview

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N Adya, L H Castilla, P P Liu. 2000. Function of CBFbeta/Bro proteins.. https://doi.org/10.1006/scdb.2000.0189

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