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Analytical considerations for microdialysis sampling.

M I Davies·J D Cooper·S S Desmond·C E Lunte·S M Lunte
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Abstract

Adaptations in microdialysis probe designs have made it possible to obtain samples from the extracellular fluid of a variety of tissues with high temporal resolution. The resulting small volume samples, often with low concentration of the analyte(s) of interest, present a particular challenge to the analytical system. Rapid separations can be coupled on-line with microdialysis to provide near real-time data. By combining microdialysis sampling with a liquid chromatographic or capillary electrophoretic separation and a highly sensitive detection method, a separation-based sensor can be developed. Such sensors have been applied to the investigation of drug entities as well as to study endogenous analytes.

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AnimalsBiosensing TechniquesChromatography, High Pressure LiquidElectrophoresis, CapillaryHumansMass SpectrometryMicrodialysisJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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M I Davies, J D Cooper, S S Desmond, C E Lunte, S M Lunte. 2000-12-15. Analytical considerations for microdialysis sampling.. https://doi.org/10.1016/s0169-409x(00)00114-9

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