PubMed HealthSearch

PubMed · 1111005

Sequential brain scanning as an adjunctive scanning procedure.

Abstract

Sequential brain scans were performed at various time intervals of up to four hours after injection of 99mTc pertechnetate in 108 patients who had previously undergone "routine" one-hour brain scans which were considered normal or equivocal. Forty-six patients were proved to have a discrete morphologic brain lesion. Pathologic processes were demonstrated by the sequential scanning technique in all but 6 cases. In nearly a third of these 46 patients (28%), careful observation of the progressive and subtle changes in radioactivity in the whole sequential scan series was necessary for detection of the lesions: they could not be appreciated on any single static scan when viewed independently.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J H Christie, R T Go, Y Suzuki, N Tonami, R L Schapiro. 1975. Sequential brain scanning as an adjunctive scanning procedure.. https://doi.org/10.1148/114.2.381

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Invasive pituitary adenoma coexisting with infiltrating temporal lobe glioma.

We have reported the case of a young man who had the uncommon coexistence of two relatively common intracranial tumors--a pituitary adenoma and a temporal lobe glioma. The pituitary adenoma invaded nerve bundles in the left cavernous sinus, but did not extend into the left temporal lobe, where an anatomically separate oligoastrocytoma was diagnosed at autopsy. Preoperative magnetic resonance imaging may assist in the diagnosis of this and similar uncommon conditions.

Adenoma, Chromophobe

Nelson's syndrome following partial pituitary microadenomectomy and pregnancy.

We report for the first time the development of Nelson's syndrome in a patient who had previously undergone unsuccessful pituitary microadenomectomy and subsequently bilateral adrenalectomy. The removal of a 3-mm portion of a microadenoma did not protect against the development of Nelson's syndrome within 3 years which was closely related to pregnancy, a previously noted association. This report suggests that the development of Nelson's syndrome depends not on the size of the initial pituitary tumour but rather on its individual potential for proliferating once free of the inhibitory effects of glucocorticoid excess.

Adenoma, Chromophobe

Gonadotrophin secretion in vitro by cells of a pituitary tumour from a patient with multiple endocrine neoplasia type I.

OBJECTIVE: The aim was to investigate the hormone secretory products of a pituitary tumour from a patient with multiple endocrine neoplasia type I (MEN I) utilizing cell culture and immunoassay techniques. DESIGN: Adenoma tissue was enzymically dispersed and established in cell culture. Medium was collected for hormone measurement after 2 days, and also after 24-hour periods during long-term culture. In addition, tissue fixed at surgery was analysed by immunocytochemistry and electron microscopy. PATIENT: The subject was a 59-year-old male with a clinical history characteristic of familial MEN I syndrome. MEASUREMENTS: Pituitary hormones in serum and culture medium were measured by fully characterized radioimmunoassays. RESULTS: Preoperative serum LH and FSH levels were normal, or slightly elevated, and there was a progressively blunted gonadotrophin response to GnRH throughout the 8 years prior to adenomectomy. TRH induced a small, paradoxical increase in serum gonadotrophin levels 2 weeks preoperatively. Post-operative pituitary hormone responses to standard stimulation tests showed an active normal pituitary. In vitro, the pituitary tumour cells secreted only gonadotrophins and glycoprotein hormone alpha-subunit. The fixed tumour tissue immunostained for alpha-subunit alone, and electron microscopy confirmed the presence of secretory granules with diameters of 100-280 nm. Gonadotrophin secretion continued throughout 77 days in long-term culture, but whilst LH was released at a steady rate, that of FSH transiently increased between days 29 and 48 in vitro. CONCLUSIONS: These data demonstrate that a pituitary tumour associated with the MEN I syndrome secreted gonadotrophins in vitro.

Adenoma, Chromophobe