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PubMed · 1111461

Monitoring myelomatosis.

J R Hobbs
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Abstract

There is evidence for the value of the following tests in the diagnosis, monitoring, and prognosis of myelomatosis: (1) serum paraprotein measurements, (2) urine paraprotein (including Bence Jones) measurements, (3) serum ablumin, (4) serum urea, (5) proteins in the urine other than those in 2, and (6) hemoglobin level. During treatment, increased rate of rise in 1 or 2, disproportionate increase in 2, emergence of related paraprotein, loss of 1 or 2 with reticulosarcomatous change, and monocytic leukemia suggest that more malignant subclones can emerge from the original myeloma clone, possibly due to drugs acting on DNA.

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Bence Jones ProteinBone NeoplasmsClone CellsHemoglobinsHumansImmunoglobulin AImmunoglobulin GMelphalanMonitoring, PhysiologicMultiple MyelomaMyeloma ProteinsPrognosisSerum AlbuminUreaJournal Article

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BibTeXRIS

J R Hobbs. 1975. Monitoring myelomatosis.. https://pubmed.ncbi.nlm.nih.gov/1111461/

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Plasma cell leukemia with pleomorphic plasma cells--a case report.

A case of plasma cell leukemia showing mostly pleomorphic plasma cells in the form of convoluted and multilobated nuclei with some having bilobed nuclei and internuclear bridges is being reported for its rarity of occurrence. Patient presented with congestive cardiac failure and features of nephropathy. There were no lytic lesions in the bone. Serum electrophoresis did not show any M-band while urine electrophoresis demonstrated Bence Jones protein confirming a light chain only type of myeloma. Patient is in remission 5 months after diagnosis. The significance of recognising such pleomorphic plasma cells is discussed.

Bence Jones Protein↗