Organic osmolyte channels: a comparative view.

P R Junankar; K Kirk

doi:10.1159/000016368

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Organic osmolyte channels: a comparative view.

P R Junankar·K Kirk

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Abstract

Cells respond to osmotic swelling by releasing inorganic ions and small organic molecules (organic osmolytes). In many cell-types, osmotic swelling results in the activation of an outwardly-rectifying anion-selective current. The channel underlying this current has a significant permeability to a number of organic osmolytes and may play a role in the hypoosmotically-activated efflux of these compounds. However, there is also evidence that the volume-regulatory efflux of organic osmolytes involves other pathways which may be selective for neutral osmolytes over anions.

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Animals Organic Chemicals Osmotic Pressure Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

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P R Junankar, K Kirk. 2000. Organic osmolyte channels: a comparative view.. https://doi.org/10.1159/000016368

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