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PubMed · 11126679

[Centromere separation and malignancy].

K Méhes
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Abstract

The centromeres of human chromosomes separate according to a "normal sequence" during mitosis. "Out-of-phase" separation and especially premature centromere division may lead to aneuploidy, and may be regarded as a manifestation of chromosome instability. Evaluation of these phenomena may contribute to a better understanding of predisposition to malignancy and to the possible screening of family members at high risk of cancer. For this reason, a more up-to-date and meticulous research of regulation and clinical significance of centromere separation is warranted.

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AnimalsCentromereGenetic Predisposition to DiseaseHumansNeoplasmsEnglish AbstractJournal ArticleReview

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K Méhes. 2000-11-12. [Centromere separation and malignancy].. https://pubmed.ncbi.nlm.nih.gov/11126679/

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