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PubMed · 11140723

[Lys3]Didemnins as potential affinity ligands.

M D Vera·A J Pfizenmayer·X Ding·D Xiao·M M Joullié
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Abstract

The synthesis and biological activity of N(epsilon)-Z-[Lys3]didemnin B are reported. This novel analogue retains antiproliferative, cytotoxic, and protein biosynthesis inhibition activities, but at reduced levels. This result suggests the use of [Lys3]didemnin derivatives as potential affinity probes for studying the molecular target(s) of the didemnin class of natural products.

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Affinity LabelsCell DivisionDepsipeptidesHumansInhibitory Concentration 50LigandsMolecular StructurePeptides, CyclicProtein BiosynthesisTumor Cells, CulturedJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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M D Vera, A J Pfizenmayer, X Ding, D Xiao, M M Joullié. 2001-01-08. [Lys3]Didemnins as potential affinity ligands.. https://doi.org/10.1016/s0960-894x(00)00585-0

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