[Chronic autoimmune thyroiditis in the child].

D Marinovic; J Léger; C Garel; P Czernichow

doi:10.1016/s0929-693x(00)00144-5

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[Chronic autoimmune thyroiditis in the child].

D Marinovic·J Léger·C Garel·P Czernichow

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Abstract

OBJECTIVE: The aim of the study was to describe the clinical characteristics and long-term follow-up of a group of children with chronic autoimmune thyroiditis. PATIENTS AND METHODS: Sixty children (age: 11.9 +/- 2.7 years) were studied in a retrospective analysis. RESULTS: At diagnosis, 34 of the children were hypothyroid (compensated hypothyroidism, n = 15; true hypothyroidism, n = 19) and 26 euthyroid. Thyroid ultrasonography showed characteristic features of heterogenicity and/or hypoechogenicity in all patients. Other autoimmune diseases were found in ten subjects (17%) and 23% had a family history of thyroid disease. At the end of the follow-up, nine of 45 children (20% of the cases) followed up for at least one year (mean follow-up 4.4 +/- 3.7 years), demonstrated a change in thyroid function. Hypothyroidism was detected in two initially euthyroid patients. Among initially hypothyroid patients, seven (28%) recovered normal thyroid function, allowing L-thyroxine withdrawal for four weeks, after 1.5 to 8.4 years. No factor was found to be predictive of the course of the disease. All subjects treated with L-thyroxine for hypothyroidism reached normal final height. CONCLUSION: The natural course of chronic lymphocytic thyroiditis is variable and unpredictable. Recovery from hypothyroidism does occur and can be aided by the L-thyroxine withdrawal test. The disease requires lifelong thyroid surveillance, especially in women during pregnancy, in order to avoid a potential adverse effect on the future child.

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Adolescent Adult Child Female Follow-Up Studies Humans Hypothyroidism Male Pregnancy Pregnancy Complications Prognosis Retrospective Studies Thyroiditis, Autoimmune Thyroxine English Abstract Journal Article

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D Marinovic, J Léger, C Garel, P Czernichow. 2000. [Chronic autoimmune thyroiditis in the child].. https://doi.org/10.1016/s0929-693x(00)00144-5

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