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deltaFosB: a molecular switch underlying long-term neural plasticity.

M B Kelz·E J Nestler
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Abstract

Numerous chronic perturbations have been shown to induce highly stable isoforms of the transcription factor deltaFosB in the brain in a region-specific manner. This review examines the functional consequences of the induction of deltaFosB in particular neuronal populations as well as its possible role in behavioral abnormalities such as drug addiction and movement disorders.

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AnimalsHumansMovement DisordersNeuronal PlasticitySubstance-Related DisordersTranscription Factor AP-1Transcription FactorsJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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M B Kelz, E J Nestler. 2000. deltaFosB: a molecular switch underlying long-term neural plasticity.. https://doi.org/10.1097/00019052-200012000-00017

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