PubMed Health⌕ Search

PubMed · 11156190

Nonlinear canonical correlation analysis by neural networks.

Abstract

Canonical correlation analysis (CCA) is widely used to extract the correlated patterns between two sets of variables. A nonlinear canonical correlation analysis (NLCCA) method is formulated here using three feedforward neural networks. The first network has a double-barreled architecture, and an unconventional cost function, which maximizes the correlation between the two output neurons (the canonical variates). The remaining two networks map from the canonical variates back to the original two sets of variables. Tested on data sets with correlated nonlinear structures, NLCCA showed that the underlying nonlinear structures could be retrieved accurately under moderately noisy conditions. After a mode had been retrieved, NLCCA was applied to the residual to successfully retrieve the next mode. When tested for prediction skills, the NLCCA outperformed the CCA when the two sets of variables contained correlated nonlinear structures.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

W W Hsieh. 2000. Nonlinear canonical correlation analysis by neural networks.. https://doi.org/10.1016/s0893-6080(00)00067-8

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Striping artifact removal in VisiumHD data through nuclear counts modeling.

MOTIVATION: 10x Genomics VisiumHD enables spatial transcriptomics at 2 µm × 2 µm resolution but exhibits slide-specific, non-periodic striping artifacts due to lane-width variability. These multiplicative row/column effects distort bin total counts and can bias downstream analyses. The state-of-the-art destriping approach is the normalization procedure used as a preprocessing step in bin2cell; it applies sequential high-quantile row- then column-wise normalization, which is asymmetric and can introduce edge effects/macro-stripes and distortions of large-scale total-count structure. RESULTS: We propose a statistical destriping approach that leverages nuclei segmentation from the co-registered H&E image. Assuming transcript abundance is constant within each nucleus, we model bin counts with a negative binomial distribution whose mean is a product of a nucleus-specific concentration and row- and column-specific stripe-factors reflecting lane-width variation. We fit all parameters in a generalized linear modeling framework with cross-validated regularization on stripe-factors and iterative dispersion estimation, and use the fitted parameters to correct the observed counts into a destriped image. On synthetic data with known ground truth, our method improves stripe-factor estimation accuracy and reduces error in corrected counts relative to bin2cell and bin2cell-derived baselines. Across four public VisiumHD slides, it consistently lowers striping intensity while substantially better preserving biological signal present in the large-scale global count structure and avoiding the artifacts introduced by other methods. AVAILABILITY AND IMPLEMENTATION: All source code and links to publicly available data used for this study are available at https://github.com/paolamalsot/destriping-GLM.

Artifacts↗

Impairment of echocardiographic acoustic window caused by breast implants.

Cosmetic breast implants are increasing in popularity. The presence of a breast implant overlying the anterior mediastinal space as a cause of impairment of the echocardiographic acoustic window has not been described previously. Here, we report three cases with significant impairment of echocardiographic acoustic window caused by breast implants. Clinicians should be aware of this interference and women should be informed of this dilemma before considering this cosmetic surgery.

Artifacts↗