BRCA1 and cell signaling.

Q Wang; H Zhang; R Fishel; M I Greene

doi:10.1038/sj.onc.1203974

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BRCA1 and cell signaling.

Q Wang·H Zhang·R Fishel·M I Greene

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Abstract

The breast cancer and ovarian cancer susceptibility gene BRCA1 encodes a nucleoprotein whose mutations or aberrant expression is associated with both inherited and sporadic cancers. Studies over the last 6 years have suggested that BRCA1 may function as a scaffold in the assembly of a multi-protein complex, which plays a role in gene transcription, DNA damage repair, and transcription-coupled DNA damage repair. In this review, we discuss the implications drawn from the studies of BRCA1-interacting proteins and the cellular signaling pathways that may be involved in controlling the functions of BRCA1.

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Animals Apoptosis BRCA1 Protein Cell Cycle Chromosome Segregation DNA Damage DNA Repair Gene Expression Regulation Humans Signal Transduction Journal Article Research Support, Non-U.S. Gov't Review

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Q Wang, H Zhang, R Fishel, M I Greene. 2000-12-11. BRCA1 and cell signaling.. https://doi.org/10.1038/sj.onc.1203974

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