Does vitamin E decrease heart attack risk? summary and implications with respect to dietary recommendations.

M G Traber

doi:10.1093/jn/131.2.395s

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Does vitamin E decrease heart attack risk? summary and implications with respect to dietary recommendations.

M G Traber

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Abstract

The hypothesis that oxidative stress has a role in atherosclerosis rests on a large body of experimental work carried out in animal models of heart disease. The situation is more complex in humans, in that the results from vitamin E supplementation trials have been conflicting. Nonetheless, there is emerging information that alpha-tocopherol may play a critical role in maintaining the function of key cellular components in the atherosclerotic process through its ability to inhibit the activity of protein kinase C, a key player in many signal transduction pathways. alpha-Tocopherol modulates pathways of platelet aggregation, endothelial cell nitric oxide production, monocyte/macrophage superoxide production and smooth muscle cell proliferation. Regulation of adhesion molecule expression and inflammatory cell cytokine production by alpha-tocopherol has also been reported. More studies are required to relate alpha-tocopherol intakes to optimal tissue responses in humans.

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Animals Antioxidants Heart Diseases Humans Models, Animal Nutrition Policy Risk Factors Vitamin E Journal Article Research Support, Non-U.S. Gov't Review

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M G Traber. 2001. Does vitamin E decrease heart attack risk? summary and implications with respect to dietary recommendations.. https://doi.org/10.1093/jn%2F131.2.395s

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