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Cell membrane-associated measles virus components inhibit antigen processing.

J Marttila·A Hinkkanen·T Ziegler·R Vainionpää·A Salmi·J Ilonen
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Abstract

Measles virus (MV)-induced immune suppression is an important reason for MV-associated mortality and morbidity. Despite numerous studies, the mechanisms of immune suppression still remain poorly defined. In the present study we analyzed the effect of MV components on the T-cell recognition of specific non-MV antigens. We demonstrated that even inactivated MV could inhibit the presentation of unprocessed protein antigen to specific T cells, whereas MV did not affect the responses of specific T cells to representative synthetic peptide epitopes derived from complex antigens. The inhibition was induced by MV-infected cell membranes. The kinetics of the MV-dependent inhibition suggested an impaired antigen processing in mononuclear cells as addition of MV-infected cell debris 4 h after the beginning of cell cultures no longer inhibited T-cell responsiveness.

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Antigen PresentationAntigen-Presenting CellsAntigens, ViralCell MembraneCells, CulturedHumansImmunosuppression TherapyKineticsLeukocytes, MononuclearMeasles virusPeptidesRubella virusT-LymphocytesJournal Article

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J Marttila, A Hinkkanen, T Ziegler, R Vainionpää, A Salmi, J Ilonen. 2001-01-20. Cell membrane-associated measles virus components inhibit antigen processing.. https://doi.org/10.1006/viro.2000.0701

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