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Apoptotic capability in ageing T cells.

J D McLeod
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Abstract

The ageing immune system shows a gradual decline in responsiveness to antigens and tumours due to the emergence of immunosenescence. The main functions of T cells are activation, anergy and apoptosis and these are all affected during ageing. Apoptosis is vital in controlling cell numbers, deleting self-reactive T cells and maintaining immune surveillance. One of the principle instigators of death involves the CD95:CD95-ligand interaction and as T cells age both receptor and ligand levels increase. This view will describe the current knowledge of the apoptotic susceptibility of ageing T cells and evaluate the factors that may affect the apoptotic capability of immunosenescent T cells.

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ApoptosisCellular SenescenceHumansImmune SystemT-LymphocytesJournal ArticleReview

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BibTeXRIS

J D McLeod. 2000-12-20. Apoptotic capability in ageing T cells.. https://doi.org/10.1016/s0047-6374(00)00206-2

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