New molecules for hippocampal development.

T Skutella; R Nitsch

doi:10.1016/s0166-2236(00)01717-3

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New molecules for hippocampal development.

T Skutella·R Nitsch

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Abstract

Pathfinding by developing axons towards their proper targets is an essential step in establishing appropriate neuronal connections. Recent work involving cell culture assays and molecular biology strategies, including knockout animals, strongly indicates that a complex network of guidance signals regulates the formation of hippocampal connections during development. Outgrowing axons are routed towards the hippocampal formation by specific expression of long-range cues, which include secreted class 3 semaphorins, netrin 1 and Slit proteins. Local membrane- or substrate-anchored molecules, such as ligands of the ephrin A subclass, provide layer-specific positional information. Understanding the molecular mechanisms that underlie axonal guidance during hippocampal development might be of importance in making therapeutic use of sprouting fibers, which are produced following the loss of afferents in CNS lesion.

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Animals Axons Carrier Proteins Dentate Gyrus Ephrin-A3 Glycoproteins Hippocampus Humans Membrane Proteins Nerve Growth Factors Nerve Tissue Proteins Netrin-1 Neural Pathways Pyramidal Cells Semaphorin-3A Tumor Suppressor Proteins Journal Article Research Support, Non-U.S. Gov't Review

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T Skutella, R Nitsch. 2001. New molecules for hippocampal development.. https://doi.org/10.1016/s0166-2236(00)01717-3

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