A mitochondrial perspective on cell death.

P Bernardi; V Petronilli; F Di Lisa; M Forte

doi:10.1016/s0968-0004(00)01745-x

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A mitochondrial perspective on cell death.

P Bernardi·V Petronilli·F Di Lisa·M Forte

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Abstract

The role of mitochondria as crucial participants in cell death programs is well established, yet the mechanisms responsible for the release of mitochondrial activators and the role of BCL2 family proteins in this process remain controversial. Here, we point out the limitations of current approaches used to monitor the physiological responses of mitochondria during cell death, the implications arising from modern views of mitochondrial structure, and briefly assess two proposed mechanisms for the release of mitochondrial proteins during apoptosis.

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Animals Apoptosis Cell Death Cell Membrane Cyclosporine Drug Resistance, Multiple Enzyme Inhibitors Mitochondria Models, Biological Protein Structure, Tertiary Proto-Oncogene Proteins c-bcl-2 Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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P Bernardi, V Petronilli, F Di Lisa, M Forte. 2001. A mitochondrial perspective on cell death.. https://doi.org/10.1016/s0968-0004(00)01745-x

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