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PubMed · 11171553

Gene targeting in hemostasis. tissue factor.

N Mackman
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Abstract

Tissue factor (TF) is the primary cellular initiator of blood coagulation. At sites of vascular injury, formation of a TF:FVIIa complex leads to the generation of FXa, thrombin and the deposition of fibrin to limit hemorrhage. In contrast to its beneficial role in hemostasis, TF initiates life-threatening intravascular thrombosis in sepsis, atherosclerosis and cancer. More recently, TF has been proposed to play a role in other biological processes, including tumor-associated angiogenesis, metastasis and inflammation. Indeed, gene targeting of TF resulted in embryonic lethality, which appeared to be due to a defect in the yolk sac vasculature.

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AnimalsBlood CoagulationBlood Coagulation DisordersGene SilencingGene TargetingHemostasisHumansMiceNeoplasm MetastasisNeovascularization, PhysiologicSignal TransductionThrombinThromboplastinYolk SacJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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N Mackman. 2001-02-01. Gene targeting in hemostasis. tissue factor.. https://doi.org/10.2741/mackman

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