Genetic models for CNS inflammation.

T Owens; H Wekerle; J Antel

doi:10.1038/84603

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PubMed · 11175845

Genetic models for CNS inflammation.

T Owens·H Wekerle·J Antel

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Abstract

The use of transgenic technology to over-express or prevent expression of genes encoding molecules related to inflammation has allowed direct examination of their role in experimental disease. This article reviews transgenic and knockout models of CNS demyelinating disease, focusing primarily on the autoimmune disease multiple sclerosis, as well as conditions in which an inflammatory response makes a secondary contribution to tissue injury or repair, such as neurodegeneration, ischemia and trauma.

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Animals Central Nervous System Chemokines Clinical Trials as Topic Cytokines Demyelinating Diseases Humans Interferon-gamma Models, Genetic Multiple Sclerosis Th2 Cells Transforming Growth Factor beta Tumor Necrosis Factor-alpha Journal Article Review

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T Owens, H Wekerle, J Antel. 2001. Genetic models for CNS inflammation.. https://doi.org/10.1038/84603

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