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Replicative DNA polymerases.

M Albà
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Abstract

SUMMARY: Replicative DNA polymerases are essential for the replication of the genomes of all living organisms. On the basis of sequence similarities they can be classified into three types. Type A polymerases are homologous to bacterial polymerases I, Type B comprises archaebacterial DNA polymerases and eukaryotic DNA polymerase alpha, and the bacterial polymerase III class make up type C. Structures have been solved for several type A and B polymerases, which share a similar architecture. The structure of type C is not yet known. The catalytic mechanism of all three types involves two metal-ion-binding acidic residues in the active site. Replicative polymerases are constitutively expressed, but their activity is regulated through the cell cycle and in response to different growth conditions.

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AnimalsDNADNA Polymerase IDNA Polymerase IIDNA Polymerase IIIDNA ReplicationDNA-Directed DNA PolymeraseEvolution, MolecularHumansProtein ConformationJournal ArticleReview

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M Albà. 2001-01-12. Replicative DNA polymerases.. https://doi.org/10.1186/gb-2001-2-1-reviews3002

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