Generating diversity at GABAergic synapses.

E Cherubini; F Conti

doi:10.1016/s0166-2236(00)01724-0

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PubMed · 11182455

Generating diversity at GABAergic synapses.

E Cherubini·F Conti

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Abstract

GABA-mediated transmission is characterized by high variability of synaptic responses. Major contributors to this variability are: presynaptic factors, including release probability and number of release sites; factors that determine synaptic GABA transients in the cleft, including diffusion and the actions of GABA transporters; and postsynaptic factors, including GABA(A) receptors subtypes, their location and number, their modulation by endogenous and exogenous factors, and their interactions with postsynaptic-anchoring proteins.

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Animals Carrier Proteins GABA Plasma Membrane Transport Proteins Humans Mammals Membrane Proteins Membrane Transport Proteins Organic Anion Transporters Phylogeny Protein Conformation Receptors, GABA-A Synapses Synaptic Transmission gamma-Aminobutyric Acid Journal Article Research Support, Non-U.S. Gov't Review

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E Cherubini, F Conti. 2001. Generating diversity at GABAergic synapses.. https://doi.org/10.1016/s0166-2236(00)01724-0

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