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PubMed · 11189387

[Experimental study on immune privilege in subretinal space].

L Gao·D Jiang
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Abstract

OBJECTIVE: To evaluate the immune characteristics of subretinal space. METHODS: Retina of DBA/2 mouse with or without Complete Freund's Adjunvate (CFA), or human peripheral blood mononuclear cell (PBMC), or syngenic retina, and DMEM as negative control were transplanted into subretinal spaces of BALB/C mouse. Delayed-type hypersensitivity (DTH) and specific killing of cytotoxic T lymphocyte (CTL) were detected two weeks later and histopathological examination was carried out as well. RESULTS: There were no significant differences in DTH between four experimental groups and control group, but the specific killing of CTL was significantly higher than that of the control group. Retinal transplant was survival. Immune rejection occurred in human PBMC group. CONCLUSION: Limited immune privilege occurs in a certain degree after subretinal space transplantation.

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AnimalsFreund's AdjuvantGraft RejectionHumansHypersensitivity, DelayedLeukocytes, MononuclearMiceMice, Inbred BALB CRetinaT-Lymphocytes, CytotoxicEnglish AbstractJournal Article

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L Gao, D Jiang. 1998. [Experimental study on immune privilege in subretinal space].. https://pubmed.ncbi.nlm.nih.gov/11189387/

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