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PubMed · 11191098

The function of eosinophils.

J K Weltman
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Abstract

What is the primary function of eosinophils? Regulatory or anti-inflammatory or pro-inflammatory? Results with IL-5 knockout mice and with IL-5R alpha knockout mice clearly show that (1) eosinophils play key roles as cellular mediators in asthma and allergy, and that (2) IL-5 is necessary for the participation of eosinophils in allergic inflammation (Foster PS et al. J Exp Med 183:195-201, 1996; Tanaka H et al. Clin Exp Allergy 30:874-881, 2000). The results obtained with IL-5 knockout mice and with IL-5R alpha knockout mice can be used to guide and inform asthma and allergy research in humans.

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AnimalsEosinophilsInflammationInterleukin-5MiceMice, KnockoutReceptors, InterleukinEditorial

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J K Weltman. The function of eosinophils.. https://doi.org/10.2500/108854100778249105

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