ATP as a presynaptic modulator.

R A Cunha; J A Ribeiro

doi:10.1016/s0024-3205(00)00923-1

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ATP as a presynaptic modulator.

R A Cunha·J A Ribeiro

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Abstract

There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy, the observations that ATP is released from stimulated central nervous system (CNS) nerve terminals and that responses to exogenously added ATP can be recorded in central neurons, lead to the proposal that ATP might also be a fast transmitter in the CNS. However, in spite of the robust expression of P2 receptor mRNA and binding to P2 receptors in the CNS, the demonstration of central purinergic transmission has mostly remained elusive. We now review evidence to suggest that ATP may also act presynaptically rather than solely postsynaptically in the nervous system.

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Adenosine Triphosphate Animals Brain In Vitro Techniques Mice Neurotransmitter Agents Presynaptic Terminals RNA, Messenger Rats Receptors, Presynaptic Journal Article Research Support, Non-U.S. Gov't Review

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R A Cunha, J A Ribeiro. 2000-12-01. ATP as a presynaptic modulator.. https://doi.org/10.1016/s0024-3205(00)00923-1

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