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PubMed · 11192170

Separation ability and stoichiometry of cyclodextrin complexes.

M Asztemborska·R Nowakowski·D Sybilska
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Abstract

Gas-liquid chromatography has been applied to search relations between selectivity towards isomers and stoichiometry of cyclodextrin complexes. The model tested compounds were: dimethylnaphthalenes and alpha- and beta-pinenes as constitutional isomers; cis/trans decalins, anetholes and isosafroles as diastereomers and as enantiomers (+/-)-alpha-pinenes and (+/-)-camphenes. Experimental retention data are used to confirm a simple theoretical model that allows distinguishing formation of G x CD complexes (1:1) and G x CD2 complexes (1:2). Based on the experimental data, stability constants K were evaluated. It has been found that remarkable selectivity factor alpha may appear both within the range of 1:1 stoichiometry (beta-CD complexes of decalins and of alpha- and beta-pinenes) and 1:2 stoichiometry (alpha-CD complexes with (+/-)-alpha-pinenes and (+/-)-camphenes). Occasionally selectivity arises from a different composition, when one isomer forms a 1:1 stoichiometry complex while another forms a 1:2 complex (dimethylnaphthalenes, cis/trans-anetholes and cis/trans-isosafroles).

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Allylbenzene DerivativesAnisolesChromatography, GasCyclodextrinsNaphthalenesSafroleStereoisomerismJournal Article

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BibTeXRIS

M Asztemborska, R Nowakowski, D Sybilska. 2000-12-15. Separation ability and stoichiometry of cyclodextrin complexes.. https://doi.org/10.1016/s0021-9673(00)00785-8

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