Alpha-azido acids for direct use in solid-phase peptide synthesis.

C W Tornøe; P Davis; F Porreca; M Meldal

doi:10.1002/1099-1387(200012)6:12<594::aid-psc276>3.0.co;2-x

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Alpha-azido acids for direct use in solid-phase peptide synthesis.

C W Tornøe·P Davis·F Porreca·M Meldal

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Abstract

Several new alpha-azido acids have been synthesized and their use in solid-phase peptide synthesis has been demonstrated. The azido group allows for high activation of the carboxyl group as an acid chloride without formation of byproducts and with no detectable racemization. An analog of Leu-enkephalin has been prepared and tested in the mouse vas deferens and guinea pig ileum bioassays: it displays moderate activity at the delta-opiod receptor.

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Animals Azides Biological Assay Enkephalins Guinea Pigs Ileum Male Mice Mice, Inbred ICR Muscle, Smooth Receptors, Opioid, delta Vas Deferens Journal Article Research Support, Non-U.S. Gov't

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C W Tornøe, P Davis, F Porreca, M Meldal. 2000. Alpha-azido acids for direct use in solid-phase peptide synthesis.. https://doi.org/10.1002/1099-1387(200012)6%3A12%3C594%3A%3Aaid-psc276%3E3.0.co%3B2-x

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