[Effect of N-acylethanolamines on adrenal cortex function].

N M Hula; O S Mikosha; O D Zhukov; I S Chelnakova

PubMed · 11200481

[Effect of N-acylethanolamines on adrenal cortex function].

N M Hula·O S Mikosha·O D Zhukov·I S Chelnakova

Abstract

The possibility of NAE to take part in the regulation of the function of adrenal glands was studied. It was shown that two times NAE (18:0) injection in a dose 5 mg/kg of weight increased the content of 11-hydroxysteroids in blood of intact male rats. NAE caused the raise of the blood hormone content by 4 times under the immobilization stress. It is apparent that augment of stress response under the influence of NAE in vivo is explained by the activation of hypophysis-adrenal cortex system. In vitro NAE lowered steroidogenesis by near 40%. One can suggest that this decrease is caused by membranotropic properties of NAE.

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Adrenal Cortex Animals Blood Pressure Ethanolamines Hydroxysteroids Immobilization Male Rats Stress, Physiological English Abstract Journal Article

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N M Hula, O S Mikosha, O D Zhukov, I S Chelnakova. [Effect of N-acylethanolamines on adrenal cortex function].. https://pubmed.ncbi.nlm.nih.gov/11200481/

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