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Staphylococcal surface display and its applications.

S Ståhl·A Robert·E Gunneriusson·H Wernérus·F Cano·S Liljeqvist·M Hansson·T N Nguyen·P Samuelson
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Abstract

Novel surface proteins can be introduced onto the bacterial cell surface by recombinant means. Here, we describe the development of such display systems for two food-grade bacteria, Staphylococcus carnosus and Staphylococcus xylosus, and present how such engineered bacteria can be used in different applications. A study will be described in which such staphylococci were employed as vaccine delivery vehicles to elicit protective antibody responses to respiratory syncytial virus (RSV). The use of surface-engineered staphylococci as novel microbial biocatalysts, as a new type of whole-cell diagnostic devices or for adsorption of metal ions with potential environmental or biosensor applications, will also be discussed.

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AnimalsDNA, BacterialDrug Administration RoutesEnzymesGenetic VectorsMetalsMucous MembranePlasmidsRecombination, GeneticStaphylococcusVaccines, SyntheticJournal ArticleReview

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S Ståhl, A Robert, E Gunneriusson, H Wernérus, F Cano, S Liljeqvist, M Hansson, T N Nguyen, P Samuelson. 2000. Staphylococcal surface display and its applications.. https://doi.org/10.1016/s1438-4221(00)80002-8

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