The reverse transcriptase model of somatic hypermutation.

E J Steele; R V Blanden

doi:10.1098/rstb.2000.0749

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The reverse transcriptase model of somatic hypermutation.

E J Steele·R V Blanden

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Abstract

The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL-6 gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of somatically mutated sequences to the germline over evolutionary time.

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Animals DNA-Binding Proteins Humans Immunoglobulin Variable Region Models, Genetic Mutation Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-6 RNA-Directed DNA Polymerase Recombination, Genetic Transcription Factors Journal Article Research Support, Non-U.S. Gov't Review

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E J Steele, R V Blanden. 2001-01-29. The reverse transcriptase model of somatic hypermutation.. https://doi.org/10.1098/rstb.2000.0749

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