Is multiple sclerosis severity a genetically influenced trait?

E Cocco; M G Marrosu

doi:10.1007/s100720070023

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Is multiple sclerosis severity a genetically influenced trait?

E Cocco·M G Marrosu

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Abstract

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system of unknown pathogenesis, is a complex disease with a multifactorial etiology determined by both genetic and environmental factors. The pathological entity MS has a wide phenotype, and also the severity of the disease is widely variable. Clinical heterogeneity of the disease might arise from different genotype-phenotype interactions. Results of recent studies and theories about the modifying role of different genes in the course and the severity of MS are here discussed.

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Apolipoproteins E Chromosomes, Human, Pair 17 Disease Progression Genetic Linkage Humans Interleukins Multigene Family Multiple Sclerosis Polymorphism, Genetic Receptors, Estrogen Journal Article Review

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E Cocco, M G Marrosu. 2000. Is multiple sclerosis severity a genetically influenced trait?. https://doi.org/10.1007/s100720070023

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