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Selenoprotein P.

M P Moschos
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Abstract

Selenoprotein P (SeP) is an extracellular, monomeric glycoprotein containing up to 10 selenocysteine residues in the polypeptide chain. It is ubiquitously expressed in mammalian tissues, and in human plasma it accounts for at least 40% of the total selenium concentration. SeP binds to heparin and cell membranes, and is associated with endothelial cells. SeP in human plasma protects against peroxynitrite-mediated oxidation and reduces phospholipid hydroperoxide in vitro, in accordance with the presumption that it has a function as an extracellular oxidant defense. Immunochemical assays have demonstrated that its concentration in plasma varies much with selenium intake, but other factors also have an influence.

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AgingAnimalsBlood ProteinsDietEuropeFemaleGlutathione PeroxidaseHumansMaleNeoplasmsOdds RatioProteinsRisk FactorsSeleniumSelenoprotein PSelenoproteinsSex CharacteristicsSmokingJournal ArticleResearch Support, Non-U.S. Gov'tReview

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M P Moschos. 2000. Selenoprotein P.. https://doi.org/10.1007/pl00000665

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