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Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?

A M Rao·J F Hatcher·R J Dempsey
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Abstract

Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. These data suggest that CDP-choline prevented the activation of phospholipase A(2) (rather than inhibiting phospholipase A(2) activity) but did not affect activities of PtdCho-phospholipases C and/or D, or phosphoinositide-phospholipase C. CDP-choline also provided significant protection for hippocampal CA(1) neurons.

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AnimalsArachidonic AcidCardiolipinsCytidine Diphosphate CholineDisease Models, AnimalEnzyme ActivationFatty AcidsGerbillinaeHippocampusInjections, IntraperitonealIschemic Attack, TransientIsoenzymesMaleNootropic AgentsPhosphatidylcholinesPhosphatidylinositolsPhospholipase DPhospholipasesPhospholipases AProsencephalonType C PhospholipasesJournal Article

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A M Rao, J F Hatcher, R J Dempsey. 2001-03-02. Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?. https://doi.org/10.1016/s0006-8993(00)03280-7

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