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Making decisions through Myc.

S Nasi·R Ciarapica·R Jucker·J Rosati·L Soucek
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Abstract

c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1-S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcription of a wide range of target genes could explain its capacity to affect multiple pathways leading to proliferation, apoptosis, growth, and transformation.

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AnimalsCell CycleCell Cycle ProteinsCell DivisionCyclin-Dependent KinasesCyclinsG1 PhaseGene Expression RegulationProto-Oncogene Proteins c-mycS PhaseTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tReview

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S Nasi, R Ciarapica, R Jucker, J Rosati, L Soucek. 2001-02-16. Making decisions through Myc.. https://doi.org/10.1016/s0014-5793(01)02118-4

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