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T cell fate specification and alphabeta/gammadelta lineage commitment.

H R MacDonald·F Radtke·A Wilson
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Abstract

The development of T cells from pluripotent stem cells involves a coordinated series of lineage-commitment steps. Common lymphoid precursors in the fetal liver or adult bone marrow must first choose between a T, B or NK cell fate. Committed T cell precursors in the thymus then differentiate into cells committed to the alphabeta or gammadelta lineages. Recent advances have been made in our understanding of the mechanisms underlying T cell fate specification and alphabeta/gammadelta lineage divergence.

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AnimalsCell DifferentiationCell LineageDendritic CellsDigestive SystemHumansKiller Cells, NaturalReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaStem CellsT-LymphocytesJournal ArticleReview

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H R MacDonald, F Radtke, A Wilson. 2001. T cell fate specification and alphabeta/gammadelta lineage commitment.. https://doi.org/10.1016/s0952-7915(00)00207-7

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