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Stability and commitment in T helper cell development.

H Asnagli·K M Murphy
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Abstract

Specialized effector activities that are required to eliminate various pathogens involve cytokines produced by specialized CD4(+) T cells subsets, dogmatically termed Th1 and Th2 cells. Despite some oversimplifications, this paradigm is useful for organizing the complex pathways that control forward and backward movements along the road of T cell differentiation. Effective immune memory relies, in part, on the maintenance of the T helper phenotype. This review will address basic issues that relate to the maintenance or reversibility of Th1/Th2 states within the CD4(+) T cell lineage.

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AnimalsCell DifferentiationHumansInterleukin-12Interleukin-4PhenotypeSTAT6 Transcription FactorTh1 CellsTh2 CellsTrans-ActivatorsTranscription FactorsTranscription, GeneticJournal ArticleReview

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H Asnagli, K M Murphy. 2001. Stability and commitment in T helper cell development.. https://doi.org/10.1016/s0952-7915(00)00210-7

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