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PubMed · 11229600

Focal adhesions: structure and dynamics.

V Petit·J P Thiery
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Abstract

Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho-dependent fashion.

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Cell AdhesionCytoskeletal ProteinsFocal AdhesionsHumansIntegrinsMembrane ProteinsModels, BiologicalSignal Transductionrho GTP-Binding ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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V Petit, J P Thiery. 2000. Focal adhesions: structure and dynamics.. https://doi.org/10.1016/s0248-4900(00)01101-1

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